How Do We Know the Importance of Nozin for Hygiene?

August 8, 2014

Studies show several factors in nose-related accumulation and transfer of pathogenic microorganisms that are relevant to an understanding of how Nozin Nasal Sanitizer can help improve hygiene.  The nose remains a persistent repository of microrbes, the nose is touched frequently and the nose is a gateway between the environment and the body. The research supports more universal adoption of nasal hygiene to help reduce community and nosocomial infections.

The nasal vestibule (area just inside of the nasal opening) is a critical site for the accumulation of a wide range of pathogenic organisms:

  • The nasal vestibules of “healthy” individuals are typically colonized by bacteria and other microbes with Staphylococcus aureus (S. aureus) being a constituent in 20-40 percent of them.
  • Reducing the nasal bacterial load of pathogens, such as S. aureus, decreases the incidence of transmission and subsequent infection by greater than 50%.1

Potentially harmful microbes may exist in the nose in the absence of symptomology:

  • Some microbes exhibit “opportunistic” activity, in that they remain dormant until underlying tissues are damaged or immuno-suppression occurs.2   
  • Bacterial growth may remain at rest until an adequate number of organisms have accumulated and a “quorum” is sensed by the microbes, triggering their rapid growth.3  

Studies have now shown that decreasing bacterial carriage in the nose can be used to reduce transmission and prevent disease in carriers of pathogenic bacteria such as S. aureus.4

  • Observational studies show that the average person touches their nose over a hundred times per day. This behavior promotes self-inoculation and transfer of pathogens.
  • A major study in hospital patients showed that nasal decolonization of all patients – not just those known to carry pathogenic bacterial strains – was the most effective approach to reducing infection in the entire test population.5

These results support the benefit of nasal hygiene and the demonstrated clinical effectiveness of Nozin Nasal Sanitizer support its use as part of infection control.6 Note that the original poster, "Reduction of Staphylococcus aureus Carriage by Non-Antibiotic NOZIN® Nasal Sanitizer® Antiseptic" was presented at ID Week by Dr. Steed. The NIH tracked the Nozin study. Results have also been published in a major article in the August 2014 issue of the American Journal of Infection Control.6


1. Lonneke G.M. Bode, Jan A.J.W. Kluytmans, Heiman F.L. Wertheim, et al. Preventing Surgical-Site Infections in Nasal Carriers of Staphylococcus aureus. New England Journal of Medicine 362:9-17, 2010.
2. Reddy S, Wanchu A, Gupta V, Bambery P. Profile of opportunistic infections among patients on immunosuppressive medication. APLAR Journal of Rheumatology 9:269-274, 2006.
3. Teresa R. de Kievit , Barbara H. Iglewski. Bacterial Quorum Sensing in Pathogenic Relationships. Infection and Immunity 68: 4839–4849, 2000.
4. Robicsek A, Beaumont JL, Thomson RB, Govindarajan G, Peterson LR. Topical therapy for methicillin-resistant Staphylococcus aureus colonization: impact on infection risk. Infect Control Hosp Epidemiol 30:623-632, 2009.
5. Huang S, Septimus,E, et al. Targeted versus universal decolonization to prevent ICU infection. N Engl JMed 368(24):2255-65 2013.
6. Steed L, Costello J, Lohia S, et al. Reduction of nasal Staphylococcus aureus carriage in health care professionals by treatment with a nonantibiotic, alcohol-based nasal antiseptic (Nozin Nasal Sanitizer). American Journal of Infection Control. Volume 42, Issue 8, Pages 841–846, August 2014.


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